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Betadex sulfobutyl ether sodium USP standard, Pharmaceutical Grade Excipient CAS#182410-00-0
Time:2022/05/14

Betadex sulfobutyl ether sodium USP standard, Pharmaceutical Grade Excipient,CAS#182410-00-0 


Betadex sulfobutyl ether sodium is a new type of anionic high soluble cyclodextrin derivatives. It could include drug molecules to from covalent compounds so that increase the drug's stability, solubility, safety. It could reduce the renal toxicity, moderate drug's hemolysis, control the release rate and cover up the bad smell. 

 

Details

Product Name Betadex sulfobutyl ether sodium 
CAS No. 182410-00-0 
Molecular Formula C42H70-nO35(C4H8SO3Na)n 
Appearance White powder, sweet, insipid and innocuous 
Standard USP
Solubility >100g (25℃, g/100ml in water) 
DMF No. 030167 
Molecular Weight 1135+158n 
Type Pharmaceutical excipient 
Grade Standard Pharmaceutical Grade Grade 
Brand Name zhiyuan 

 Product Specification

Standard  USP
ITEMS SPECIFICATION 
Clarity of Solution 

A 30%w/v solution in water is clear and essentially free from 

particles of foreign matter 

Identification (IR) Same absorption bands as USP betadex sulfobutyl ether sodium RS 
Identification(Sodium) Identify test are positive for Sodium 
Identification(LC) 

the retention time of the major peak of sample solution 

corresponds to the standard solution 

Average Degree of 

Substitution 

6.2-6.9 
Water solution pH pH of 30%w/v solution in water is 4.0-6.8 
Water content ≤10.0% 
β-Cyclodextrin Content ≤0.1% 
Sodium Chloride ≤0.2% 
1,4-butane sultone ≤0.5ppm 
4-Hydroxybutane-1-Sulfonic Acid ≤0.09% 
Disodium bis-(4-sulfobtyl) ether ≤0.05% 
Assay 95.0%-105.0% 
Bacterial endotoxins ≤20EU/g 
Microbiology 
TAMC ( cfu/g) ≤100 cfu/g 
TYMC ( cfu/g) ≤50 cfu/g 
Escherichia Coli Absence 

Main Application

Betadex sulfobutyl ether sodium is used as a solubilizer, stabilizer, wetting agent, chelating agent (complexing agent) and polyvatent masking agent in Injection, Oral, Nasal and Eye medicines.

 

Packing & Shipping

Packing Detail: 500g/bag, 1kg/bag, 2kg/bag, 10kg/drum

Shipping term: By Express,by air,by sea


Delivery & Payment

Payment : T/T in advance, LC at sight, DP at sight

Delivery  : Within 1-2 days after receipt the payment.


Advantages

1.It is an important modified production of Beta-Cyclodextrin.

2.It is mainly used in the azotic medicine as an excipient.

3.It is a new type of anionic high water-soluble cyclodextrin derivatives.

4.It is good at including of drug molecules to form covalent compounds so that improve the stability of drugs, water-solubility, security, reduce renal toxicity, moderate drug hemolytic,control drugs release rate, cover up the bed smell .

5.It has been used for injectable,oral, nasal, eye medication.For Nitrogen drugs has a special affinity and inclusion.


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